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 OpenWrt 22.03.4, r20123-38ccc47687
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root@spitz:~# dmesg | grep ttyUSB
[   41.985360] usb 1-1.2: GSM modem (1-port) converter now attached to ttyUSB0
[   41.999671] usb 1-1.2: GSM modem (1-port) converter now attached to ttyUSB1
[   42.013903] usb 1-1.2: GSM modem (1-port) converter now attached to ttyUSB2
[   42.028209] usb 1-1.2: GSM modem (1-port) converter now attached to ttyUSB3

My loss of ttyUSB2 was sporadic, and I think the cause may have been related to lots of modem up/down events and probably me resetting the modem. I haven’t lost the ttyUSB2 device recently.