Best setting for excluding certain domain?

Hello all. I am new to networking and just got my Flint 2 while I wait for the Flint 3 (was using a raspberry pi as a router with OpenWRT and don't want to wait any longer). I am trying to exclude a certain domain using the setting "VPN Policy Based on the Target Domain or IP". After some research, I see that I also need to turn off the setting for AdGuard Home "AdGuard Home Handle Client Requests". This seems to be working but is this the best setting for this scenario? I have AdGuard Home handling my DNS. So does this mean the Upstream DNS Servers setting in AdGuard Home is Obsolete now? Thank you in advanced for the help.

This one isn't necessary anyway. It just allows AdGuard to know the IP addresses of your devices. As long as you don't have filter based on devices in AdGuard, you can disable this without issues.

Thank you for the reply @admon. Are you referring to Access settings under Settings > DNS settings towards the bottom of the page? If so, I am not using that so it's safe to use my configuration and turn off "Adguard Home Handle Client Requests"?