Iβve just started trying wireguard on my old MT300N. I have a very good speed with Wireguard. I was having slightly different issue. I wasnβt able to connect to certain https sites even though MSS (I presume this is the mtu_fix param) was on. It turned out that lowering MTU size on wg interface solves the issue.
Default value of MTU on wg interface was 1420. Following command does the trick:
ifconfig wg mtu 1360