Upgrade to 4.5 killed AdGuard Home

I know you said you have adguard disabled but just double check again. Toggle off both adguard options and make sure your VPN client / server is toggled off too. Go to Network > DNS and apply manual DNS and select something like cloudflare (1.1.1.1) apply and then try and pull / run the script again. I have had this happen before and it's usually a case of just applying some custom DNS again after toggling adguard and VPN off.

When you re-enabled adguard then you can toggle on handle clients too if that option was previously on / you want that feature.

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